Clarification

Is the ‘Holy Spirit’ in this verse anything to do with belief in ‘Trinity’?

In short

The Holy Spirit with which God supported Jesus was the Angel Gabriel.

Answer

The reference in this verse (see also 2:87, 253) is to the Angel Gabriel, as becomes clear from 16:102, which affirms that this same Holy Spirit (Ruh al-Qudus) brings the revelation to Prophet Muhammad ﷺ (cf. 2:97, 26:192-195). Gabriel is also referred to as a ‘Spirit’ in other verses (e.g. 19:17, 26:193).

The repeated use of this designation in verses speaking of Prophet Jesus (peace be upon him) is likely intended to correct misconceptions around this name and concept, as Jesus was indeed supported by the angelic spirit sent by the One God. The Quran invites people back to the purest conception of monotheism, and recognizing both the Angel and the Prophet as God’s honored servants.

Sources cited

Ibn ‘Ashur, Al-Tahrir wa ‘l-Tanwir
Ibn ‘Atiyyah, al-Muharrar al-Wajiz
Ibn Kathir, Tafsir al-Qur’an al-Azim
Al-Shinqiti, Adwa’ al-Bayan

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Verses cited

5:110 Al-Ma'idah إِذْ قَالَ ٱللَّهُ يَـٰعِيسَى ٱبْنَ مَرْيَمَ ٱذْكُرْ نِعْمَتِى عَلَيْكَ وَعَلَىٰ وَٰلِدَتِكَ إِذْ أَيَّدتُّكَ بِرُوحِ ٱلْقُدُسِ تُكَلِّمُ ٱلنَّاسَ فِى ٱلْمَهْدِ وَكَهْلًا ۖ وَإِذْ عَلَّمْتُكَ ٱلْكِتَـٰبَ وَٱلْحِكْمَةَ وَٱلتَّوْرَىٰةَ وَٱلْإِنجِيلَ ۖ وَإِذْ تَخْلُقُ مِنَ ٱلطِّينِ كَهَيْـَٔةِ ٱلطَّيْرِ بِإِذْنِى فَتَنفُخُ فِيهَا فَتَكُونُ طَيْرًۢا بِإِذْنِى ۖ وَتُبْرِئُ ٱلْأَكْمَهَ وَٱلْأَبْرَصَ بِإِذْنِى ۖ وَإِذْ تُخْرِجُ ٱلْمَوْتَىٰ بِإِذْنِى ۖ وَإِذْ كَفَفْتُ بَنِىٓ إِسْرَٰٓءِيلَ عَنكَ إِذْ جِئْتَهُم بِٱلْبَيِّنَـٰتِ فَقَالَ ٱلَّذِينَ كَفَرُوا۟ مِنْهُمْ إِنْ هَـٰذَآ إِلَّا سِحْرٌ مُّبِينٌ Then God will say, ‘Jesus, son of Mary! Remember My favour to you and to your mother: how I strengthened you with the holy spirit, so that you spoke to people in your infancy and as a grown man; how I taught you the Scripture and wisdom, the Torah and the Gospel; how, by My leave, you fashioned the shape of a bird out of clay, breathed into it, and it became, by My leave, a bird; how, by My leave, you healed the blind person and the leper; how, by My leave, you brought the dead back to life; how I restrained the Children of Israel from [harming] you when you brought them clear signs, and those of them who disbelieved said, “This is clearly nothing but sorcery”;

In short

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