What is the "sin" (ithm) that is present in alcohol (khamr)?

Imām Ibn al-Jawzī (d. 597/1201) summarized the scholars' opinions in his book "Zād al-Masīr" as follows:

1. Drinking it diminishes one’s religion. [Ibn ʿAbbās]
2. When a person drinks, he becomes intoxicated and will cause harm to others. [Al-Suddī]
3. It leads to enmity and hatred, and it covers the mind, which is necessary for proper judgment. [Al-Zajjāj]